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Xa i-dihydrotanshinone ndibulala i-Helicobacter pylori, ayinakutshabalalisa kuphela i-biofilm, kodwa ikwabulala neebhaktiriya eziqhotyoshelwe kwi-biofilm, edlala indima "ekususeni" i-Helicobacter pylori.

U-Bi Hongkai, uNjingalwazi, iSikolo soNyango olusisiseko, iYunivesithi yaseNanjing yezoNyango

Idatha yomhlaza yamva nje yomhlaba ibonisa ukuba phakathi kwezigidi ezingama-4.57 zezigidi zomhlaza omtsha e-China minyaka le, i-480,000 yamatyala amatsha omhlaza wesisu, abalwa nge-10.8%, aphakathi kwezintathu eziphezulu. E-China eneziganeko eziphezulu zomhlaza wesisu, inqanaba losulelo lwe-Helicobacter pylori liphezulu njenge-50%, kwaye ingxaki yokuchasana ne-antibiotic iya isiba mandundu ngakumbi, ikhokelela ekwehleni okuqhubekayo kwinqanaba lokupheliswa.
Kutshanje, iqela likaNjingalwazi Bi Hongkai, iSikolo sezoNyango esiSiseko, iYunivesithi yaseNanjing yezoNyango, livavanye ngempumelelo umgqatswa omtsha weziyobisi kwiHelicobacter pylori-Dihydrotanshinone enganyangekiyo ngamachiza. -I-Helicobacter pylori biofilm, ukhuseleko kunye nokunganyangeki, njl. Iziphumo zapapashwa kwi-intanethi kwiphephancwadi elinegunya lokulwa ne-antimicrobial "iAntimicrobial Agents kunye neChemotherapy".

Inqanaba lokuqala lokusilela kunyango kunyango lwesintu lumalunga ne-10%

Ngaphantsi kwemicroscope, ubude zii-micrometer eziyi-2.5 ukuya kwii-4, kwaye ububanzi zii-micrometer eziyi-0.5 ukuya kwi-micrometer enye. I-Helicobacter pylori, ibhakteria ejijekileyo engumoya "eyasasaza amazinyo kunye nemidaniso yeenzipho", ayinakubanga kuphela isifo esibuhlungu nesingapheliyo, izilonda zesisu kunye nezomzimba kunye ne-lymphatics. Izifo ezinjenge-gastric lymphoma eyandayo ikwanxulumene nomhlaza wesisu, umhlaza wesibindi kunye neswekile.

Unyango oluphindwe kathathu kunye noluneziqu ezinee-antibiotics ezimbini zihlala zisetyenziswa kwilizwe lam ukunyanga i-Helicobacter pylori, kodwa iindlela zonyango zesiko azinakho ukuyiphelisa iHelicobacter pylori.

“Inqanaba lokusilela kunyango lokuqala kunyango lwesintu lumalunga ne-10%. Ezinye izigulana ziya kuba nohudo okanye ukuphazamiseka kwentsholongwane esiswini. Ezinye ziyaliwa yipenicillin, kwaye zimbalwa i-antibiotics onokukhetha kuzo. Kwangelo xesha, ukusetyenziswa kwexesha elide kwamayeza okubulala iintsholongwane kuya kubangela ibhaktiriya. U-Bi Hongkai uthe: “Iintsholongwane ziyanyangeka kwi-antibiotics ezithile, kwaye ziyakuxhathisa nakwezinye i-antibiotics, kwaye ukuxhathisa nako kuyahluka ngeendlela ezahlukeneyo. Intsholongwane iyasasazeka ngokusebenzisa iiseli zemfuza ezinganyangekiyo ngamachiza, nto leyo eyenza kube nzima ukunganyangeki ngamachiza ziintsholongwane. ”

Xa iHelicobacter pylori ixhathisa ukuhlaselwa lutshaba, iyakwenza ngobuqhetseba i-biofilm “inshorensi yokukhusela” yona, kwaye i-biofilm iya kuba nokumelana namayeza okubulala iintsholongwane, okukhokelela ekunyukeni kokuchasana ne-Helicobacter pylori, echaphazela isiphumo sonyango kunye nokunciphisa inqanaba lokunyanga.

I-Salvia miltiorrhiza yocwaningo lweseli inokuthintela iintlobo ezininzi ezinganyangekiyo ngamachiza

Ngo-1994, uMbutho wezeMpilo weHlabathi wachaza iHelicobacter pylori njengeCarcinogen yodidi I kuba idlala indima ekhokelayo ekwenzekeni nasekuphuculweni komhlaza esiswini. Ungasusa njani umbulali wezempilo? Kwi-2017, iqela likaBi Hongkai lenze impumelelo ngokwenza uvavanyo lokuqala-eDanshen.

I-Danshen lelinye lawona mayeza esintu asetyenziswa kakhulu amaTshayina ekukhuthazeni ukujikeleza kwegazi kunye nokususa i-stasis yegazi. Iziphumo zayo ezinyibilikayo ezityebileyo zizinto ze-tanshinone, kubandakanya ngaphezulu kwe-30 monomers ezinje nge-tanshinone I, dihydrotanshinone, tanshinone IIA, kunye ne-cryptotanshinone. Iimpawu zeTanshinone zineempembelelo ezahlukeneyo ze-pharmacological, ezinjenge-anti-cancer, anti-positive bacteria, anti-inflammatory, estrogen-like activity and cardiovascular protection, njl njl.

“Ngaphambili, sihlolisise ngaphezu kwe-1 000 i-monomers zamayeza amaTshayina kwinqanaba leseli, kwaye ekugqibeleni sigqibe kwelokuba i-dihydrotanshinone I monomer eDanshen ibe nezona ziphumo zibalaseleyo ekubulaleni iHelicobacter pylori. Xa sisenza iimvavanyo zeseli, safumanisa ukuba xa uxinzelelo lwe-dihydrotanshinone bendisetyenziswa Xa ingu-0.125 μg / ml-0.5 μg / ml, inokuthintela ukukhula kweentlobo ezininzi zeHelicobacter pylori, kubandakanya ne-antibiotic-sensitive and multi-drug strains . ” U-Bi Hongkai uthe i-dihydrotanshinone ndiyasebenza kakhulu ngokuchasene ne-Helicobacter pylori kwi-biofilms. Iziphumo ezilungileyo zokubulala, kunye noHelicobacter pylori khange akhule ngokuchasene ne-dihydrotanshinone I ngexesha lokuhamba okuqhubekayo.

Ummangaliso omkhulu kukuba “Xa i-dihydrotanshinone ndibulala i-Helicobacter pylori, ayikwazi ukutshabalalisa kuphela i-biofilm, kodwa ikwabulala neebhaktiriya eziqhotyoshelwe kwi-biofilm, edlala indima 'ekuqandeni' iHelicobacter pylori. “U-Bi Hongkai wazisiwe.

Ngaba i-Dihydrotanshinone inokunyanga i-Helicobacter pylori?

Ukwenza iziphumo zovavanyo zichaneke ngakumbi, iqela likaBi Hongkai likwaqhube novavanyo lweempuku ukujonga ngakumbi ukubulawa kwe-dihydrotanshinone I kwi-Helicobacter pylori.

U-Bi Hongkai wazise ukuba kuvavanyo, kwiiveki ezimbini emva kokuba iimpuku zosulelwe yi-Helicobacter pylori, abaphandi babahlulahlula ngokwamaqela ama-3, angala qela lolawulo lihlanganisiweyo le-omeprazole kunye ne-dihydrotanshinone I, iqela lolawulo lwemilinganiselo emithathu, kunye ne-phosphoric acid iqela lokulawula i-buffer, iimpuku zanikwa amayeza kanye ngemini ngeentsuku ezi-3 ezilandelelanayo.

"Iziphumo zovavanyo zibonisa ukuba iqela lolawulo elidityanisiweyo le-omeprazole kunye ne-dihydrotanshinone ndinobuchule obuphezulu ekubulaleni i-Helicobacter pylori kuneqela eliqhelekileyo lerejimeni." U-Bi Hongkai uthe, oko kuthetha ukuba kwiimpuku, i-dihydrotanshinone ndinokubulala okuphezulu kunamayeza emveli.

Ndiza kungena nini eDihydrotanshinone kumakhaya abantu abaqhelekileyo? U-Bi Hongkai ugxininise ukuba i-Danshen ayinakusetyenziswa ngokuthe ngqo ukuthintela nokunyanga usulelo lwe-Helicobacter pylori, kunye ne-monomer yayo dihydrotanshinone Isekude ukuba yenziwe ichiza elinokusetyenziswa eklinikhi. Uthe inyathelo elilandelayo liza kuqhubeka lifunda ngendlela yokusebenza kwe-dihydrotanshinone I, kunye nokuphucula i-pharmacology kunye ne-toxicology ye-dihydrotanshinone I ngokuchasene ne-Helicobacter pylori. “Indlela esa phambili ayisahambi. Ndiyathemba ukuba iinkampani zingathatha inxaxheba kuphando lwangaphambi kweklinikhi kwaye ziqhubeke nolu phando ukuze kuncedwe abaguli abaninzi abanezifo zesisu. ”